According to the official update log, the cumulative update primarily fixes localized improvements that resulted in the reinstallation of applications that have been uninstalled after each reboot, logoff, and log in, and error alerts such as JET database corruption.
The cumulative update was originally launched with the October patch Tuesday event, which included fixes for the kernel-mode driver, the Microsoft Graphics component, the IE browser, and the Windows DNS Service. According to a known issue of KB4043961, the installation of a generic application that uses JavaScript and asm.js stops working after installation.